ea0014p143 | (1) | ECE2007
Franchi Giulia
, Grozinsky-Glasberg Simona
, de Oliveira Antonio Ribeiro
, Salahuddin Nabila
, Korbonits Márta
, Grossman Ashley B.
Background: Somatostatin analogues are very useful in the treatment of symptomatic neuroendocrine tumours, but effects on proliferation remain unclear. Overexpression of the proto-oncogene protein kinase Akt has been demonstrated in certain endocrine tumours, and activates downstream proteins including mTOR and p70S6K, which play a significant role in cell growth and proliferation. We have therefore explored the site of action of somatostatin in causing inhibition of prolifera...